Which blood group system antigens are destroyed by enzymes?

Which blood group system antigens are destroyed by enzymes?

• A. Lutheran
• B. Kell
• C. Lewis
• D. MNS

Answer: (A)

Enzymes that digest red cell surface proteins can remove or alter certain antigenic determinants. Lutheran antigens (Lu a and Lu b) are known to be destroyed by proteolytic treatment, so their reactivity disappears after enzyme exposure. That makes Lutheran the best match for an antigen system whose antigens are destroyed by enzymes. The other listed systems have different responses to enzyme treatment and aren’t consistently destroyed in the same way, so they don’t fit this pattern as reliably.

Enzymes that digest red cell surface proteins can remove or alter certain antigenic determinants. Lutheran antigens (Lu a and Lu b) are known to be destroyed by proteolytic treatment, so their reactivity disappears after enzyme exposure. That makes Lutheran the best match for an antigen system whose antigens are destroyed by enzymes. The other listed systems have different responses to enzyme treatment and aren’t consistently destroyed in the same way, so they don’t fit this pattern as reliably.