What is the most common Rh negative genotype?

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Prepare for the MT AAB Immunohematology Test with our quiz! Study with flashcards and multiple choice questions with hints and explanations. Get ready for your exam today!

Multiple Choice

What is the most common Rh negative genotype?

Explanation:
The presence of the D antigen is what determines Rh positivity. Rh negative individuals typically lack D because both chromosomes carry a D-negative background. The cde haplotype is the common D-negative RH background; having two copies of it means no D antigen is expressed on either chromosome. Therefore, cde/cde results in the Rh negative phenotype, making it the most frequent genotype for someone who is D-. The other possibilities involve at least one D-positive haplotype, which would produce a D antigen and thus a D+ phenotype.

The presence of the D antigen is what determines Rh positivity. Rh negative individuals typically lack D because both chromosomes carry a D-negative background. The cde haplotype is the common D-negative RH background; having two copies of it means no D antigen is expressed on either chromosome. Therefore, cde/cde results in the Rh negative phenotype, making it the most frequent genotype for someone who is D-. The other possibilities involve at least one D-positive haplotype, which would produce a D antigen and thus a D+ phenotype.

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